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Recombivax HB

hepatitis B vaccine (Engerix B)

By Merck

What is this medication for?

Hepatitis B vaccine prevents infection by hepatitis B by allowing your body to produce its own protection (antibodies) against the disease. Hepatitis B virus is a major cause of serious liver diseases such as hepatitis, cirrhosis, and liver cancer. Hepatitis B vaccine is recommended for persons of all ages (including newborns), especially those at increased risk of infection with hepatitis B virus, for example:

  • adolescents
  • blood bank workers
  • health care personnel
  • infants, including those born to mothers with hepatitis B
  • military personnel
  • morticians and embalmers
  • people who have chronic hepatitis C
  • people from certain areas at high risk of hepatitis B infection (e.g., Alaskan Eskimos, Pacific Islanders, Indochinese immigrants, Haitian immigrants)
  • people and their contacts in certain hospital clinics (e.g., dialysis, cancer, blood transfusion patients) or institutions for people who are mentally handicapped
  • people requiring frequent or large-volume blood transfusions or other blood products
  • people traveling to high-risk areas
  • people who engage in high-risk sexual activity
  • prisoners
  • users of illicit injectable drugs

Your doctor may have suggested this medication for conditions other than those listed here. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it. Do not stop taking this medication without consulting your doctor.

What form(s) does this medication come in?

Recombivax HB® is available as:

  • vials
    • 5 µg per 0.5 mL
    • 10 µg per 1.0 mL
    • 40 µg per 1.0 mL (for dialysis patients only)
  • syringes
    • 5 µg per 0.5 mL
    • 10 µg per 1.0 mL
Some medications may have other generic brands available. Always ask your doctor or pharmacist about the safety of switching between brands of the same medication.

How should I use this medication?

A qualified health professional will inject the hepatitis B vaccine. The dose varies according to age and dosing schedule. The dose of hepatitis B vaccine is injected into a muscle (preferably the upper, outer arm for adults and the thigh for infants and young children) with 3 doses that are at least one month apart. Injection at 0, 1, and 6 months is a common dosing schedule. A 2-dose regimen is available for adolescents (11 to 15 years of age) where the second dose is given 4 to 6 months after the first. For people who are at risk of bleeding after an injection into the muscle (e.g., people with hemophilia), hepatitis B vaccine may be injected under the skin.

The vaccine must be shaken before use.

Store this vaccine in the refrigerator and keep it out of the reach of children. The vaccine must not freeze or it will have to be discarded.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. Other dosing schedules are sometimes used.

It is very important to keep doctor appointments so that this medication may be used according to recommended schedules. If you miss a scheduled dose, it may affect how well this vaccine works.

Who should NOT take this medication?

Hepatitis B vaccine should not be used by anyone who:

  • is allergic to hepatitis B-containing vaccine or any ingredient of this vaccine
  • is allergic to yeast
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